Towards a target label-free suboptimum oligonucleotide displacement-based detection system
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چکیده
منابع مشابه
Towards a target label-free suboptimum oligonucleotide displacement-based detection system
A novel method for the future development of label-free DNA sensors is proposed here. The approach is based on the displacement of a labelled suboptimum mutated oligonucleotide hybridised with the immobilised biotin-capture probe. The target fully complementary to the biotin-capture probe can displace the labelled oligonucleotide causing a subsequent decrease of the signal that verifies the pre...
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ژورنال
عنوان ژورنال: Analytical and Bioanalytical Chemistry
سال: 2008
ISSN: 1618-2642,1618-2650
DOI: 10.1007/s00216-008-2119-4